Paradoxical reactions might take place like hallucinations, aggressive behavior, and psychoses; dinscontinue use if reactions occur
Use of benzodiazepines, such as diazepam, both applied by yourself and in combination with other CNS depressants, may produce probably lethal respiratory melancholy
Pitfalls of dependence and withdrawal maximize with for a longer time treatment method period and better daily dose; Though injection is indicated only for intermittent use, if utilised a lot more frequently than advisable, abrupt discontinuation or immediate dosage reduction may well precipitate acute
Coadministration of zuranolone with other CNS depressants might maximize impairment of psychomotor effectiveness or CNS depressant consequences. If unavoidable, look at dose reduction. .
Drugs that have step therapy connected with Each and every prescription. This restriction typically requires that certain criteria be achieved just before approval for the prescription.
lorlatinib will lessen the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
If it's not feasible, give drug into tubing of a flowing IV Remedy as shut as you can to vein insertion
As a result of isolated reports of neutropenia and jaundice, periodic blood counts and liver purpose tests are sensible in the course of extensive-phrase therapy
Neonatal withdrawal syndrome and signs suggestive of floppy toddler syndrome affiliated with administration of benzodiazepines over the later levels of pregnancy and peripartum time period happen to be claimed Benzodiazepines cross the placenta and will create respiratory despair, hypotonia, and sedation in neonates; monitor neonates subjected to therapy in the course of pregnancy or labor for indications of sedation, respiratory depression, hypotonia, and feeding complications; keep recommended reading an eye on neonates exposed to therapy during pregnancy for signs of withdrawal; regulate these neonates accordingly Animal details
fluvoxamine will improve the degree or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
diazepam raises amounts of lomitapide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Lomitapide dose shouldn't exceed 30 mg/day.
dasatinib will enhance the amount or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
If any withdrawal response develops, consider pausing taper or rising dose to former tapered dosage level; subsequently lower dose extra gradually
Whilst not usually lethal when taken by itself, a diazepam overdose is taken into account a medical crisis and customarily needs the instant attention of healthcare staff. The antidote for an overdose of diazepam (or another benzodiazepine) is flumazenil (Anexate). This drug is barely Utilized in situations with significant respiratory melancholy or cardiovascular problems. Simply because flumazenil is a brief-performing drug, and the consequences of diazepam can past for days, a number of doses of flumazenil might be necessary.